Credit: Teisha Rowland

MCDB faculty members in developmental biology investigate the molecular and cellular mechanisms that underlie the differentiation of cells, the formation of tissues, and the development of organs and organisms. Research programs cover a broad range of developmental events in a variety of model systems, ranging from unicellular organisms to invertebrates, plants, flies, worms, rodents and humans. Topics include signal transduction in fertilization and organogenesis; molecular dynamics of neuronal differentiation, plasticity, and degeneration; and genetics and genomics of cell growth and programmed cell death. Stem cell research programs investigate the roles of adult and embryonic stem cells in normal development, as well as their potential in regenerative therapies for kidney disease, eye disorders, and neural degeneration. Interdisciplinary collaborations stimulate novel approaches that combine state of the art technologies from molecular biology, bioinformatics, and bioengineering. Interactions among groups, seminars, journal clubs, and courses in developmental and stem cell biology proved a rich and supportive environment for learning and discovery.

Affiliated Faculty

Professor, Wilcox Family Chair in BioMedicine
Human stem cell research; Molecular mechanisms of stem cell differentiation; Derivation of ocular cells from stem cells; Soft tissue regeneration.
Professor
Molecular mechanisms of self/non-self recognition in non-vertebrates; characterization of stem cells and development processes underlying regeneration and aging.
Professor
Biochemistry and Cell Biology of Neuronal Development; Biochemistry of Neurodegenerative Diseases; Structure, Function and Regulation of the Microtubule Associated Protein, Tau; Cytoskeletal Regulation.
Professor
Molecular genetics of plant development; analysis of abscisic acid signaling networks.
Professor
Faculty Graduate Advisor
Graduate Diversity Officer
Our research mission is to understand the molecular basis of gamete recognition and the fine tuning of one time only cellular activation events.
Harriman Professor of Neuroscience
Neural plasticity including the molecular basis of plasticity, the evolution of synapses, and disease-related impairments of plasticity such as occurs in Alzheimer's disease.
Duggan Professor and Distinguished Professor
Combination of molecular, genetic, and state-of-the-art imaging approaches to define and solve fundamental questions in cell and developmental biology with implications for neurodegenerative disease, ischemic diseases and cancer.
Research Professor
Professor Emeritus
Tetrahymena genetics and genomics; genetic, physical and sequence mapping of the germline and expressed genomes of the unicellular eukaryote, Tetrahymena thermophila.
Associate Professor
Collaboration with the Low and Hayes labs on contact-dependent growth inhibition systems in bacteria.
Assistant Professor
We investigate DNA repair mechanisms and use this knowledge to improve gene editing.
Professor and Wilcox Family Chair in Biotechnology
Regulation of development and differentiation; regulation of programmed cell death and cell division; mechanisms of tumorigenesis.
Professor
Developmental genetics and morphogenesis of the primitive chordate Ciona.
Distinguished Professor
Studies the self-renewal and pluripotency of stem cells.
Professor
Investigation of molecular mechanisms underlying polycystic kidney disease (PKD) and related renal diseases. Membrane trafficking and epithelial cell polarity.
Assistant Professor
Combines tools from Biology, Engineering, and Physics to understand the cell’s perceptual field.