Conducting research at the intersection of biology and nanotechnology in exciting new interdisciplinary collaborations that combine the approaches of biochemistry, molecular biology, and biotechnology with the expertise of colleagues in the Departments of Materials Science, Physics, Chemistry and Chemical Engineering, we are discovering the molecular mechanisms governing several biological processes that have technological consequences:
Molecular biology of plant secondary metabolism; biochemistry of ethylene synthesis.
Molecular cell biology of plant-microbe symbiosis, structure and function of plant cell walls, bioinformatics of tandem repeat proteins.
Biochemistry; protein structure and function relationships; protein dynamics; chemotaxis in bacteria.
Molecular mechanisms of self/non-self recognition in non-vertebrates; characterization of stem cells and development processes underlying regeneration and aging.
Biochemistry and Cell Biology of Neuronal Development; Biochemistry of Neurodegenerative Diseases; Structure, Function and Regulation of the Microtubule Associated Protein, Tau; Cytoskeletal Regulation.
Molecular genetics and biochemistry of bacterial contact-dependent growth inhibition (CDI) systems; mechanisms of tmRNA- and ArfA-mediated ribosome rescue.
Molecular mechanisms of signal transduction; Alzheimer's Disease and other protein aggregation/misfolding diseases; molecular biology, enzymology, and protein structure/function.
Nanomedicine in Biomedical Discovery, Diagnosis, and Therapeutics that Target the Molecular and Cellular Origins of Disease.
Bio-inspired catalytic nanofabrication, tunable photonic materials and dynamic self-assembly. Applications to semiconductors, high-power batteries, electro-optics, IR and solar energy.
Nanoscale assembled structures in biological systems; structures of lipid-DNA complexes; supramolecular assembly of cell cytoskeletal proteins; development of lipid-based vectors for gene and drug delivery.
Antiviral innate immunity and interferon action, with focus on the roles of double-stranded RNA in translational control by the PKR kinase and A-to-I RNA editing by the ADAR1 deaminase.
Cell biology of the nervous system and muscle. Mechanisms of ion channel trafficking; function and regulation of potassium channels; polarized targeting of membrane proteins and neuronal cell polarity.
Structure-properties relationships in loadbearing marine biomolecular materials, e.g. from mussels, squid and whelks, at different length and time scales to design new materials.
Mechanism and regulation of microtubule polymerization and dynamics; mechanism of action of microtubule-targeted anticancer drugs and microtubule-regulatory proteins.
Molecular, Cellular, and Developmental Biology •
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