Awards / Honors
- Searle Scholar
- National Science Foundation Presidential Faculty Fellow
- UCSB Plous Award
- UCSB Chancellor's Award for contributions to Undergraduate Research
- UCSB Distinguished Teaching Award (MLPS)
After earning a BS in Biological Sciences at Bowling Green State University (Ohio), Dr. Foltz pursued her PhD at Purdue University (1985-1989), where she worked with Dr. David Asai on the cell biology and biochemistry of microtubule based motility. She then pursued postdoctoral research as an NRSA-NIH Postdoctoral Scholar at the State University of New York-Stony Brook with Dr. William Lennarz, studying the molecular basis of gamete recognition in echinoderms. Dr. Foltz joined the faculty at UCSB in 1993.
Our research is focused on elucidating the molecular mechanisms of gamete recognition and subsequent egg activation. Fertilization triggers extremely rapid and dramatic changes in the composition and architecture of protein complexes in the egg. These changes ultimately manifest in the ability of the activated egg to transition to an embryo. We use many species of marine invertebrates, such as sea urchins, sea stars and ascidians, to address these phenomena. Both large-scale biochemical approaches (including high throughput proteomic analyses) as well as single cell (microinjection and microscopic imaging) experiments can be conducted using the large, synchronously-developing eggs of these free spawning animals, which share the basic aspects of egg activation with other species, including mammals.
Guo, H, Garcia-Vedrenne, AE, Isserlin, R, Lugowski, A, Morada, A, Sun, A, Miao, Y, Kuzmanov, U, Wan, C, Ma, H, Foltz, K, Emili, A (2015). Phosphoproteomic network analysis in the sea urchin Strongylocentrotus purpuratus reveals new candidates in egg activation. Proteomics 15, 4080-4095.
Roux, MM, and Foltz, KR (2014). Isolation and assessment of signaling proteins from synchronized cultures during egg activation and through the egg-to-embryo transition in sea urchins. Developmental Biology of the Sea Urchin and Other Marine Invertebrates: Methods and Protocols. Methods in Molecular Biology 1128:277-294.
Adams, NL, Campanale, JP and Foltz, KR (2012). Proteomic responses of sea urchin embryos to stressful ultraviolet radiation. Integrative and Comparative Biology. 52(5):665-680.
Townley, IK, Schuyler, E, Parker-Gur, M and Foltz, KR (2009). Expression of multiple Src family kinases in sea urchin eggs and their function in Ca2+ release at fertilization. Developmental Biology. 327, 465-477.
Roux, MR, Radeke, MJ, Goel, M, Mushegian, A and Foltz, KR (2008). 2DE identification of proteins exhibiting turnover and phosphorylation dynamics during sea urchin egg activation. Developmental Biology. 313, 630-647.
Roux, MM, Townley, IK, Raisch, M, Reade, A, Bradham, C, Humphreys, G, Gunaratne, HJ, Killian, CE, Moy, G, Su, Y-H, Ettensohn, CA, Wilt, F, Vacquier, VD, Burke, RD, Wessel, G, and Foltz, KR (2006). A functional genomic and proteomic perspective of sea urchin calcium signaling and egg activation. Developmental Biology 300, 416-433.
Bradham, CA, Foltz, KR, Beane, WS, Arnone, MI, Rizzo, F, Coffman, JA, Mushegian, A, Goel, M, Morales, J, Geneviere, A-M, Lapraz, F, Robertson, AJ, Kelkar, H, Loza-Coll, M, Townley, IK, Raisch, M, Roux, MM, Lepage, T, Gache, C, McClay, DR, and Manning, G. (2006). The sea urchin kinome: A first look. Developmental Biology 300, 180-193.
Sea Urchin Genome Sequencing Consortium* (2006). The genome of the sea urchin Strongylocentrotus purpuratus. Science. 314, 941- 952.