Phone: (805) 893-4745
Office: 3119 LSB
Molecular, Cellular, and Developmental Biology
University of California, Santa Barbara
Santa Barbara, CA 93106-9625
I conducted my graduate research at the Chemistry Department of UC Berkeley where I worked on gene regulation and DNA supercoiling in bacteria with Dr. J. Hearst, as well as bacterial multi-drug transporters with Dr. H. Nikaido. I then became a postdoctoral fellow in the group of Dr. Lily Jan at UC San Francisco and studied the trafficking of potassium channels in neurons. I started my research group at UC Santa Barbara in 2004.
(1) Membrane trafficking/cell migration and histone H3 lysine 4 (H3K4) methyltransferases. Covalent modifications of histones regulate the structure and function of chromatin. Among them, methylation of H3K4 is associated with actively transcribed genes and thus extensively studied. Unexpectedly, we have discovered that a pool of mDpy-30, a common subunit of many H3K4 methyltransferases, resides at the Golgi apparatus and it plays a role in membrane trafficking and cell migration. We are investigating the mechanism by which mDpy-30 regulates these events.
(2) AGS3 and addiction. A major difficulty in the treatment of drug addiction is the prevention of relapse. Whereas AGS3 protein, a G-protein regulator, is implicated in the modulation of recurring cocaine- and alcohol-seeking behavior in animal models of addiction, the cellular event(s) controlled by AGS3 remain incompletely characterized. Our lab has shown a link between AGS3 and Golgi structure/function and we are dissecting the pathway involved. Our long term goal is to elucidate how AGS3 regulates addictive behavior.