Phone: (805) 893-2028
Office: 3105 LSB
Molecular, Cellular, and Developmental Biology
University of California, Santa Barbara
Santa Barbara, CA 93106-9625
Dr. Hayes received his B.A. (Biology) and M.S. (Applied Immunology) degrees from the University of Southern Maine, and his Ph.D. in Molecular Biology & Biochemistry from the University of Connecticut School of Medicine. He was a Walter Winchell-Damon Runyon Cancer Research Fund postdoctoral fellow at the Massachusetts Institute of Technology and joined the MCDB faculty in 2004.
The Hayes lab studies the molecular biology and biochemistry of prokaryotic ribonucleases that regulate gene expression and cell growth. The two main research interests revolve around the mechanisms of ribosome rescue and the function of cytotoxic nucleases encoded by contact-dependent growth inhibition (CDI) systems. Bacterial ribosome rescue is mediated by the transfer-messenger RNA (tmRNA) and alternative ribosome rescue (ArfA) quality control systems, which co-operate to maintain active ribosome pools. CDI systems are widely distributed throughout α, β and γ-proteobacteria and function in growth competition. Many of these systems deploy toxic nucleases that are delivered into the cytosol of susceptible target bacteria. We are interested in the mechanisms of nuclease delivery, activation and immunity during CDI.