Dr. Morrissey attended the University of Notre Dame, earning a BS in Biological Sciences. She then completed her PhD at Duke University, studying how extracellular matrix informs cell behavior during development and cancer metastasis. Dr. Morrissey went on to do postdoctoral research in Ron Vale's lab at UCSF. At UCSF, she developed a research program studying macrophage cell biology. Dr. Morrissey joined the faculty at UCSB in the fall of 2020.
Macrophages patrol our tissues looking for signs of injury or infection. The Morrissey Lab wants to understand how macrophages measure, add and subtract all the signals they receive to calculate their response to a target. We use high resolution live imaging, synthetic biology and biochemistry to figure out when and where signaling molecules are activated to make these essential decisions. We are motivated by re-wiring macrophage signaling pathways to generate new cancer immunotherapies.
CD47 ligation repositions the inhibitory receptor SIRPA to suppress integrin activation and phagocytosis. Morrissey MA, Kern N, Vale RD. Immunity. 2020 Aug 8. doi: 10.1016/j.immuni.2020.07.008.
Chimeric antigen receptors that trigger phagocytosis. Morrissey MA, Williamson AP, Steinbach AM, Roberts EW, Kern N, Headley MB, Vale RD. Elife. 2018 Jun 4;7:e36688. doi: 10.7554/eLife.36688. PMID: 29862966
SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane. Morrissey MA, Jayadev R, Miley GR, Blebea CA, Chi Q, Ihara S, Sherwood DR. PLoS Genet. 2016 Feb 29;12(2):e1005905. doi: 10.1371/journal.pgen.1005905. eCollection 2016 Feb. PMID: 26926673
B-LINK: a hemicentin, plakin, and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes. Morrissey MA, Keeley DP, Hagedorn EJ, McClatchey STH, Chi Q, Hall DH, Sherwood DR. Dev Cell. 2014 Nov 10;31(3):319-331. doi: 10.1016/j.devcel.2014.08.024. Epub 2014 Oct 23. PMID: 25443298