Phone: (805) 893-5597
Office: 3306 LSB
Molecular, Cellular, and Developmental Biology
University of California, Santa Barbara
Santa Barbara, CA 93106-9625
Bachelor of Science in biology from UC San Diego, Master's of Science in microbiology from San Diego State University, Ph.D. in cellular biochemistry from UC Irvine, Postdoctoral work at Stanford University in molecular microbiology in Stanley Falkow's laboratory. Professor for 13 years at the University of Utah Health Sciences Center before moving to UC Santa Barbara in 1998. Co-founder of Remedyne, 2000; Vice-Chair MCDB, 2004-2008.
My primary research interest concerns cellular communication in the bacterial world. Specifically, my laboratory focuses on the biology and mechanisms involved in contact-dependent growth inhibition (CDI). We first reported this phenomenon in 2005, in which one bacterial cell touches another, injecting a small peptide effector/toxin called the CdiA-CT. The Hayes laboratory has discovered that CdiA-CTs have diverse activities including ribonucleases and deoxyribonucleases. We have shown that these systems are expressed by many bacterial species including important pathogens such as Salmonella and uropathogenic Escherichia coli. CDI systems may play important roles in intra-species competition and coordination of cellular activities via cell-to-cell contact. Our goal is to determine how these systems contribute to the lifestyle of bacteria and their mechanisms of action. Another interest of my laboratory is in mechanisms of epigenetic regulation, specifically DNA methylation patterns. We are working with Mustafa Khammash to develop a predictive model for the pyelonephritis-associated pili (Pap) epigenetic regulatory system.