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Home » People » Faculty
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Duane Sears

Professor

Contact Information

Phone: (805) 893-3499
Email: sears@lifesci.ucsb.edu
Office: 1113 LSB

Address

Molecular, Cellular, and Developmental Biology
University of California, Santa Barbara
Santa Barbara, CA 93106-9625

Bio

Professor Sears has been on the faculty at the University of California Santa Barbara campus since 1977 following completion of his postdoctoral studies on the biochemistry of murine MHC antigens in Stanley Nathenson's laboratory at Albert Einstein College of Medicine. Prior to this, he earned his Ph.D. in Biophysical Chemistry at Columbia University where he analyzed the kinetics of immunoglobulin heavy and light chain assembly for his doctoral thesis studies in Professor Sherman Beychok's laboratory, sparking his life-long interest in immunology. Since arriving at UCSB, the unifying theme of his research projects has been the analysis of various immunologically-related cell killing mechanisms. This work is underscored by a fundamental interest in understanding the function-structure relationships of proteins as reflected in the instructional web sites he has developed for his protein biochemistry and immunology courses.

Selected Publications

  • D. L. Zeger, P. M. Hogarth, and D. W. Sears. "Characterization and Expression of an Fcg Receptor cDNA cloned from Rat Natural Killer Cells." Proc. Natl. Acad. Sci. USA 81:5204-5208 (1990).
  • D. W. Sears, N. Osman, B. Tate, I. F. C. McKenzie, and P. M. Hogarth. "Molecular Cloning and Expression of the Mouse High Affinity Fc Receptor for IgG." J. Immunol. 144:371-378 (1990).
  • J. E. Christiaansen and D. W. Sears. "Unusually Efficient Tumor Cell Lysis by Human Effectors of Antibody-Dependent Cellular Cytotoxicity Mediated by Monoclonal Antibodies." Cancer Res. 44:3712-3718 (1984).
  • S. S. Burnside, P. Hunt, K. Ozato, and D. W. Sears. "A Molecular Hybrid of the H-2Dd and H-2Ld Genes Expressed in the dm1 Mutant." Proc. Natl. Acad. Sci. USA 81:5204-5208 (1984).

MCDB Research Areas

  • Biochemistry & Biomaterials
  • Microbiology & Immunology

Campus Affiliations

  • Biomolecular Science and Engineering Program

Molecular, Cellular, and Developmental Biology • University of California, Santa Barbara
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