Unraveling the Mystery of Stem Cells
MCDB neuroscientists document some of the first steps in the process by which a stem cell transforms into different cell types. How do neurons become neurons? They all begin as stem cells, undifferentiated and with the potential to become any cell in the body. Until now, however, exactly how that happens has been somewhat of a scientific mystery. New research conducted by UCSB neuroscientists led by MCDB professor Ken Kosik has deciphered some of the earliest changes that occur before stems cells transform into neurons and other cell types. Working with human embryonic stems cells in petri dishes, postdoctoral fellow Jiwon Jang discovered a new pathway that plays a key role in cell differentiation. The findings appear in the journal Cell.