Schizophrenia in a Dish
UCSB played an important role in revealing how illness-linked genetic variation affects neurons. Scientific consensus holds that most major mental disorders, such as schizophrenia, are genetically rooted diseases of synapses, the connections between neurons in the brain. New research has demonstrated how a rare mutation in a suspect gene corrupts the on-off switches of dozens of other genes underlying these connections in patients’ cells. The study appears online in the current issue of the journal Nature and was co-authored by MCDB’s Ken Kosik and members of his Molecular and Cellular Neurobiology Lab.